The WHO defined 6 key functions that people value most, including mobility, cognition, nutrition/vitality, mental health, vision and hearing, which as a composite outcome define intrinsic capacity. To monitor and strengthen intrinsic capacity, the WHO established the ICOPE, which has been increasingly adopted by researchers and clinicians… Read More »ICOPE Trial
We harmonize 10 clinical trials with phenotyping on ICOPE functions “mobility, mental health, cognition, vision, hearing and nutrition/vitality”. The consortium defined a shared concept on how to derive the composite endpoint “intrinsic capacity” from the six ICOPE functions to repurpose… Read More »repurposing 10 RCTs with IC as outcome
For the RCT, we first propose a two-arm randomized controlled pilot trial that will enroll 50 participants for the XPRIZE Semi-Finals to evaluate the effects of our personalized multimodal lifestyle intervention combined with metformin. After a screening process on 5… Read More »XPRIZE Healthspan competition