A third generation DNAm clock that measures the speed of aging Global Health Span Extension Consortium activity by Terrie E. Moffitt, MBE, PhD Terry Moffitt is a partner of the Global Health Span Consortium and leads the team that developed… Read More »DunedinPACE activity
We are pleased to announce, that the Global Healthspan Extension Consortium has a new team member: Hans Groth
We are pleased to announce, that the Global Healthspan Extension Consortium has a new team member: Andrea B. Maier
We are pleased to announce, that the Global Healthspan Extension Consortium has a new team member: Terrie E. Moffitt
While observational studies and small pilot trials suggest that vitamin D, omega-3 and exercise may slow biological aging, larger clinical trials testing these treatments individually or in combination are lacking. Here, we report the results of a post hoc analysis… Read More »Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial
The WHO defined 6 key functions that people value most, including mobility, cognition, nutrition/vitality, mental health, vision and hearing, which as a composite outcome define intrinsic capacity. To monitor and strengthen intrinsic capacity, the WHO established the ICOPE, which has been increasingly adopted by researchers and clinicians… Read More »ICOPE Trial
We harmonize 10 clinical trials with phenotyping on ICOPE functions “mobility, mental health, cognition, vision, hearing and nutrition/vitality”. The consortium defined a shared concept on how to derive the composite endpoint “intrinsic capacity” from the six ICOPE functions to repurpose… Read More »repurposing 10 RCTs with IC as outcome
For the RCT, we first propose a two-arm randomized controlled pilot trial that will enroll 50 participants for the XPRIZE Semi-Finals to evaluate the effects of our personalized multimodal lifestyle intervention combined with metformin. After a screening process on 5… Read More »XPRIZE Healthspan competition